Shree SKR Globals

Low dose naltrexone has been used to treat:

• Autoimmune thyroid disorders
• Cancer
• Chronic fatigue syndrome
• Chronic pain
• Crohn’s disease
• Fibromyalgia
• Gulf War syndrome
• Multiple sclerosis
• Myalgic encephalomyelitis.

Using low dose naltrexone for these conditions is “off-label” (which means it hasn't been approved by the FDA but it is still a recognized use).

There actually haven't been many big trials at all investigating low dose naltrexone, but the benefits of low dose naltrexone became apparent when people on a tapering schedule of naltrexone reported improvement in pain and fatigue symptoms with lower dosages of naltrexone rather than higher dosages. Small trials have shown that low dose naltrexone is beneficial for some conditions such as fibromyalgia, Crohn's disease, and pain.

Genryzon 60mg Injection is a long-acting recombinant human growth hormone (GH) analogue used to treat growth hormone deficiency in children and adolescents aged three years and above. This medication promotes normal growth by stimulating bone and muscle development and helps maintain a balanced ratio of fat and muscle tissues. It is produced using recombinant DNA technology, where cells are modified in a lab to create the active substance somatrogon.

Apart from treating growth deficiencies, Genryzon 60mg Injection Injection aids in improving muscle mass, bone density, and overall body composition. However, it is contraindicated in individuals with severe obesity, active cancer, diabetes, acute critical illness, sleep apnea, hypersensitivity, and other severe conditions. If you or your child experience difficulty breathing, rapid heart rate, swelling, or severe allergic reactions, contact your doctor immediately.

Patients with a history of heart problems, diabetes, cancer, or thyroid dysfunction should inform their healthcare provider before starting treatment. It is unknown if Genryzon 60mg Injection affects fertility. Use of this medication during pregnancy is not recommended, and it is advised to consult your doctor if pregnant, planning a pregnancy, or breastfeeding.

Product Description:
Zisavel 100 Isavuconazole Capsules contain Isavuconazole, an antifungal medication used to treat serious fungal infections, particularly invasive aspergillosis and mucormycosis. Isavuconazole is a triazole antifungal that works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. This inhibition disrupts the integrity of the fungal cell membrane, leading to cell death.

Common indications for Zisavel 100 Isavuconazole Capsules include:

• Fungal Infection Treatment: Used in the management of invasive aspergillosis and mucormycosis.

Dosage and Administration:

• For Adults: The typical dose is one 100 mg capsule taken orally once daily after a loading dose period, as prescribed by the healthcare provider. The exact dosage and duration of treatment are determined based on the patient's condition and response to therapy.
• Administration: Zisavel should be taken with or without food, following the specific instructions provided by the healthcare provider.

Common side effects of Zisavel 100 Isavuconazole Capsules may include:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Liver function abnormalities

Serious side effects can include severe allergic reactions, liver toxicity, and QT interval prolongation. Regular monitoring of liver function and heart function is essential during treatment.

Packaging:
Zisavel 100 Isavuconazole Capsules are typically packaged in a box containing 14 capsules, with each capsule individually sealed to ensure proper dosage and patient safety.

Zisavel 100 Isavuconazole Capsules are a crucial treatment option for managing severe and potentially life-threatening fungal infections such as invasive aspergillosis and mucormycosis. Due to the serious nature of these infections and the potential for significant side effects, treatment with Isavuconazole should be closely monitored by a healthcare professional. Regular monitoring of liver function, heart function, and overall patient health is essential during therapy.

Product Description: Thyrox 50 Tablet contains Thyroxine (Levothyroxine), a synthetic form of the thyroid hormone T4. It is used to treat hypothyroidism by supplementing or replacing the natural thyroid hormones in the body, helping regulate metabolism, energy levels, and overall hormonal balance. It is also prescribed in conditions requiring thyroid suppression therapy.

The medication is typically taken in the morning on an empty stomach, at least 30 minutes before food, as directed by a healthcare provider. Adjustments in dosage may be necessary based on periodic thyroid function tests. Common side effects include symptoms of overtreatment, such as nervousness, sweating, or palpitations, and should be reported to a doctor.

Nicogum Transdermal 14 mg Patch 7's belongs to a group of medications called nicotine replacement therapy (NRT) used to reduce the craving for smoking and tobacco use. Nicotine is a chemical present in tobacco that causes addiction. Taking nicotine through smoking or chewing tobacco for a prolonged period causes nicotine addiction that increases the risk of various medical problems like heart disease, lung disease and cancer.

Nicogum Transdermal 14 mg Patch 7's contains Nicotine that acts as a smoking cessation aid. It helps quit smoking and tobacco use by slowly adjusting your body to have less craving to use nicotine. As a result, over a period of time, you will not crave nicotine anymore.

You are advised to use Nicogum Transdermal 14 mg Patch 7's for the duration your doctor prescribes based on your medical condition. Sometimes, you may experience itchy skin, skin-blushing rash, dizziness, headache, nausea, vomiting, stomach pain or hives (skin rash triggered by a reaction to medicines, food or other irritants). Most of these side effects of Nicogum Transdermal 14 mg Patch 7's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Nicogum Transdermal 14 mg Patch 7's or any other medicines, please inform your doctor. Do not use Nicogum Transdermal 14 mg Patch 7's if you are a non-smoker. Avoid using Nicogum Transdermal 14 mg Patch 7's if you are breastfeeding, as nicotine is found in breastmilk that may harm your infant. If you are pregnant, try to quit smoking without using medicines containing nicotine or use Nicogum Transdermal 14 mg Patch 7's only after consulting your doctor. Nicogum Transdermal 14 mg Patch 7's is not recommended for children below 18 years. If your child uses or swallows a patch accidentally, consult your doctor immediately.

This medication contains bupropion, the same active ingredient as some antidepressant medications (Aplenzin, Forfivo, Wellbutrin). A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as bupropion during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. The combination of dextromethorphan and bupropion is not approved for use in children under 18 years of age.

You should know that your mental health may change in unexpected ways when you take the combination of dextromethorphan and bupropion even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; anxiety or panic attacks; difficulty falling asleep or staying asleep; aggressive, angry, or violent behavior; irritability; acting without thinking; severe restlessness; abnormal thoughts or sensations; feeling that people are against you; hallucinations (seeing things or hearing voices that do not exist); feeling confused; frenzied abnormal excitement; or any other sudden or unusual changes in behavior. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

No matter what your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

Your healthcare provider will want to see you often while you are taking the combination of dextromethorphan and bupropion, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.

• Risdone 4 Tablet is used in the treatment of schizophrenia (a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave) and mania. Risdone 4 Tablet is taken with or without food, preferably at night.

Bdsure (Leuprolide Acetate) 22.5mg Injection is a gonadotropin-releasing hormone (GnRH) agonist used to regulate hormone levels by reducing the production of testosterone in men and estrogen in women. It is administered as a long-acting injection to treat various hormone-sensitive conditions.

• Prostate Cancer (advanced or metastatic)

• Endometriosis (reduces estrogen to relieve symptoms)

• Uterine Fibroids (shrinks fibroids before surgery)

• Precocious Puberty (early puberty in children)

Leuprolide initially increases hormone levels before causing a long-term suppression of testosterone or estrogen production, slowing disease progression.

• Given as an intramuscular (IM) or subcutaneous (SC) injection by a healthcare professional.

• 22.5mg is typically administered every 3 months, but dosing schedules vary based on condition.

• Hot flashes, sweating

• Fatigue, headache

• Injection site reactions

• Mood changes, depression

• Bone thinning (osteoporosis risk with long-term use)

• May cause an initial hormone surge (tumor flare) in prostate cancer before suppression occurs.

• Regular bone density monitoring is recommended for long-term users.

• Not suitable for pregnant or breastfeeding women.

Bdsure should only be administered under strict medical supervision with regular follow-ups.

Tagrisso (Osimertinib) 80mg Tablet is an EGFR tyrosine kinase inhibitor (TKI) used for the treatment of non-small cell lung cancer (NSCLC) with specific EGFR mutations. It works by targeting and blocking mutated epidermal growth factor receptor (EGFR) proteins, helping slow or stop cancer growth.

• First-line treatment for EGFR-mutated NSCLC (exon 19 deletions or exon 21 L858R mutations).

• Treatment of advanced/metastatic NSCLC after progression on prior EGFR-TKI therapy, especially for T790M-positive mutations.

• Adjuvant therapy after tumor removal in EGFR-positive NSCLC.

• Standard dose: 80mg once daily, with or without food.

• Swallow the tablet whole; do not crush or split.

• Diarrhea, nausea

• Skin rash, dry skin

• Fatigue

• Low blood cell counts

• Lung inflammation (rare but serious)

• Regular lung and heart monitoring (risk of interstitial lung disease and heart problems).

• Can cause QT prolongation (affecting heart rhythm).

• Avoid in pregnancy and breastfeeding due to potential harm to the fetus.

Tagrisso should be taken under strict medical supervision with regular follow-ups.